4-HO-EPT

4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R₄ of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R_N of its tryptamine backbone (EPT).

Like with most psychedelic tryptamines, 4-HO-EPT is thought to act principally as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-HO-EPT's binding efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 4-HO-EPT

The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-EPT is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

4-HO-EPT is not habit-forming, and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-EPT is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 4-HO-EPT. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.^{[citation needed]}
• Tramadol - Tramadol is well-documented to lower the seizure threshold^[1] and psychedelics may act to trigger seizures in susceptible individuals.^{[citation needed]}

Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.

• Germany: 4-HO-EPT is controlled under the NpSG^[2] (New Psychoactive Substances Act) as of July 18, 2019.^[3] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.^[4][5] The legislator considers it possible that orders of 4-HO-EPT are punishable as an incitement to place it on the market.^[6]
• Switzerland: 4-HO-EPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.^[7]
• United Kingdom: 4-HO-EPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.^[8]
• United States: 4-HO-EPT is unscheduled in the United States. It may be considered an analogue of psilocin (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.^{[citation needed]}

• Responsible use
• Research chemical
• EPT
• Tryptamine

• 4-HO-EPT (Wikipedia)
• 4-HO-EPT (Isomer Design)
• 4-HO-EPT (Bluelight)