Talk:5-MeO-EiPT

5-MeO-EiPT, or 5-methoxy-N-methyl-N-isopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 5-MeO-EiPT is substituted at R₅ of its indole heterocycle with a methoxy (MeO) functional group CH₃O−; it also contains an ethyl group and an isopropyl chain bound to the terminal amine R_N of its tryptamine backbone (MiPT).

5-MeO-EiPT's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist^[1] and additional mechanisms of action such as the inhibition of MAO (i.e. digestive enzymes in the stomach) have also been speculated upon, though this has yet to be demonstrated scientifically. Like other 5-MeO tryptamines, it may bind more strongly to the 5-HT_1A receptor than the 5-HT_2A receptor; however, due to the paucity of research on 5-MeO-EiPT specifically, this is speculation.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index.

The toxicity and long-term health effects of recreational 5-MeO-EiPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-EiPT is a research chemical with extremely little history of human usage.

Anecdotal evidence from people within the community who have tried 5-MeO-EiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

5-MeO-EiPT is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 5-MeO-EiPT is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 5-MeO-EiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 5-MeO-EiPT all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• 2C-T-X - Both classes of compounds can be unpredictable alone.
• 2C-X - The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics.
• Cannabis - May increase the risk of negative psychological effects such as anxiety, paranoia, and psychosis.
• DOx - The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
• MDMA - Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care.
• Mescaline - The 5-MeO class of tryptamines can be unpredictable in their interactions.
• NBOMe - The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided.
• Amphetamines - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
• Cocaine - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
• DXM - Little information exists about this combination.
• Tramadol - Increased risk of serotonin syndrome.
• aMT - Increased risk of serotonin syndrome.
• MAOIs - Increased risk of serotonin syndrome.
• PCP - Little information exists about this combination. May increase risk of psychosis and excessive stimulation.

• New Zealand: 5-MeO-EiPT is an analogue of DMT which makes it a Class C controlled drug in New Zealand.^[2]
• United Kingdom: 5-MeO-EiPT is a Class A drug in the UK as it is an ether of the drug 5-HO-EiPT, which is a Class A drug as a result of the tryptamine catch-all clause.^[3]
• United States: 5-MeO-EiPT is unscheduled in the United States. It may be considered an analogue of 5-MeO-DiPT, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.^[4]

• Responsible use
• Psychedelics
• Tryptamines
• 5-MeO-DMT
• 5-MeO-DiPT
• 5-MeO-MiPT

• 5-MeO-MiPT (Wikipedia)
• 5-MeO-EiPT (TiHKAL / Isomer Design)