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Amantadine can cause life-threatening heart complications and death.

It is strongly discouraged to use this substance in high doses. Please see this section for more details.


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Chemical Nomenclature
Common names Amantadine, Midantan, Mantadix, PK-Merz, Symmetrel
Substitutive name Amantadine
Systematic name Adamantan-1-amine
Class Membership
Psychoactive class Dissociative / Deliriant
Chemical class Adamantane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 25 mg
Light 100 - 300 mg
Common 300 - 450 mg
Strong 450 - 600 mg
Heavy Heavy doses may result in fatal heart complications.
Total 12 - 48 hours
Onset 30 - 90 minutes
Peak 3 - 5 hours
Offset 24 - 48 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: Amantadine

Amantadine is a hallucinogen and weak stimulant of the adamantane class that produces long-lived dissociative and deliriant effects when administered. It is a derivative of amantadine and is pharmacologically related to compounds like memantine, rimantadine and adapromine.

Amantadine was first synthesized in the 1960s as a antiviral drug for the treatment of influenza. It was serendipitously discovered in 1969 that amantadine possesses central dopaminergic stimulant-like properties and it was introduced for the treatment of Parkinson's disease due to its ability to increase dopamine levels in the brain.[1]

Deaths have been reported from overdose with amantadine.[2] Its use can lead to cardiac, respiratory, renal or central nervous system toxicity.[3]

It is highly advised to use harm reduction practices if using this substance.



This chemistry section is incomplete.

You can help by adding to it.

Amantadine is a substituted adamantane derivative, organic compound adamantan-1-amine, meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions.



This pharmacology section is incomplete.

You can help by adding to it.

Further information: NMDA receptor antagonist

Amantadine is a weak antagonist NMDA receptors (Ki = 10 µM)[4], increases dopamine release, and blocks dopamine reuptake.[5] As well amantadine inhibits nicotinic acetylcholine receptors (nAChRs).[6]

It was discovered that amantadine binds to and acts as agonist of the σ1 receptor (Ki = 7.44 µM), and that activation of the σ1 receptor is involved in the dopaminergic effects.[7]

The mechanisms for amantadine's antiviral and psychotropic effects are unrelated. The mechanism of amantadine's antiviral activity involves interference with the viral protein, M2, a proton channel.[8]

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In addition to dissociative effects, amantadine also manifests anticholinergic effects and higher dosages can result in delirium.

Visual effects

Cognitive effects

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Experience: Amantadine(Oral administration)- A terrible experience

Toxicity and harm potential

Amantadine can hase serious side effects at higher dosages. High levels of amantadine consumption are associated with an increased risk of renal failure[9], peripheral edemas, increased heart insufficiency, and leukopenia and neutropenia.[5] Amantadine accumulates in patients with renal dysfunction.[10] In addition deaths have been reported from overdose with amantadine. Reports of amantadine fatalities indicate that doses of more that 2g are potentially lethal.[11]

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Amantadine can produce dependence with chronic use, though amantadine withdrawal syndrome is a rare event. Abrupt cessation and changes in amantadine dosage can produce a severe withdrawal syndrome which can produce delirium and neuroleptic malignant syndrome.[12][13][14]

Amantadine presents cross-tolerance with all dissociatives, meaning that after the consumption of amantadine all dissociatives will have a reduced effect.

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Amantadine has very limited information on drug combinations and should therefore be treated with extreme caution when combined with other drugs.

  • Stimulants - Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined.
  • Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
  • Deliriants - Combining amantadine with antimuscarinics such as datura, diphenhydramine, and nutmeg can severely increase BPM and BP, and as such, cardiac arrest, hypertensive crisis, as well as delirium.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Russia: Amantadine is available through a prescription.
  • China: Amantadine is available through a prescription.

See also

External links


  1. Neurological Disorders: Course and Treatment |
  2. Fatal overdose with amantadine. ( / NCBI) |
  3. DRUGBANK Amantadine |
  4. Therapeutic brain concentration of the NMDA receptor antagonist amantadine. ( / NCBI) |
  5. 5.0 5.1 Adamantane derivatives: Pharmacological and toxicological properties (review) |
  6. Amantadine inhibits nicotinic acetylcholine receptor function in hippocampal neurons. ( / NCBI) |
  7. Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine. ( / NCBI) |
  8. Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. ( / NCBI) |
  9. Obstructive acute renal failure related to amantadine intoxication. ( / NCBI) |
  10. Clinical Pharmacokinetics of Amantadine Hydrochloride |
  11. Amantadine-induced coma |
  12. The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status. ( / NCBI) |
  13. Acute delirium after withdrawal of amantadine in Parkinson's disease. ( / NCBI) |
  14. A Case Report of Severe Delirium after Amantadine Withdrawal. ( / NCBI) |
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