Talk:DMXE - PsychonautWiki


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Summary sheet: DMXE
Chemical Nomenclature
Common names DMXE
Substitutive name Deoxymethoxetamine
Systematic name 2-(ethylamino)-2-(3-methylphenyl)cyclohexan-1-one
Class Membership
Psychoactive class Dissociative / Hallucinogen
Chemical class Arylcyclohexylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Deoxymethoxetamine (also known as DMXE) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered.

DMXE has been sold online since around October 2022, marketed as a legal replacement for MXE. [1]

Limited data exists about the pharmacological properties, metabolism, and toxicity of DMXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.

History and culture


This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.



This chemistry section is incomplete.

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DMXE, like the majority of dissociatives, belongs to the class of arylcyclohexylamines. It is derived from MXE, having the methoxy residue replaced with a methyl residue [2]. DMXE's molecular formula therefore lacks an oxygen, which results in more hydrophobic and less bulky structure - causing the slight differences in pharmacology.



This pharmacology section is incomplete.

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DMXE acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.

Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually the equivalent of a "k-hole".

An in silico study showed that DMXE binds to the same site of NMDARs as MXE and posseses comparable potency [2]

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Disconnective effects

Visual effects

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational DMXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

This is because DMXE is a research chemical with a very brief history of human usage.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

External links

(List along order below)


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  1. Alert from NDEWS Web Monitoring team: Increases in Reddit discussions of DMXE, October 2020–March 2021 |
  2. 2.0 2.1 Irie, T., Yanase, Y., Demizu, Y., Usami, M., & Kikura-Hanajiri, R. (2022). Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. In Journal of Pharmacological Sciences (Vol. 150, Issue 4, pp. 233–243). Elsevier BV. [1]
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