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Summary sheet: MXPr
Chemical Nomenclature
Common names MXPR
Substitutive name 3-MeO-2′-Oxo-PCPr
Systematic name 2-(Propylamino)-2-(3-methoxyphenyl)cyclohexanone
Class Membership
Psychoactive class Dissociative
Chemical class Arylcyclohexylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 5 - 10 mg
Light 10 - 30 mg
Common 30 - 60 mg
Strong 60 - 90 mg
Heavy 90 mg +
Total 2 - 5 hours
Onset 20 - 60 minutes
After effects 4 - 48 hours

Threshold 5 - 10 mg
Light 10 - 30 mg
Common 30 - 50 mg
Strong 50 - 80 mg
Heavy 80 mg +
Total 1.5 - 4 hours
Onset 2 - 5 minutes
After effects 2 - 12 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


3-MeO-2'-Oxo-PCPr (commonly known as MXPr) is a novel dissociative substance of the arylcyclohexylamine class. It is structurally analog of MXE.

The circumstances surrounding MXPr's origins are unknown. It first appeared on the online research chemical market in 2019 and was specifically marketed as a legal substitute for MXE or ketamine.

Limited data exists about the pharmacological properties, metabolism, and toxicity of MXPr in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.


MXPr or 2-(Propylamino)-2-(3-methoxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine.

MXPr is a homolouge of MXE with a N-propyl group instead of an N-ethyl group.


Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

The effects of MXPr resemble MXE, DCK, HXE rather than O-PCE or MXiPr, which are described as more chaotic in nature. Compared to MXE, it does possesses less the warmth and produces a more disoriented headspace.

Physical effects

Visual effects

Cognitive effects

Auditory effects

Disconnective effects

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational MXPr use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

The lethal dosage of MXPr is not known. Based on it's effect it could probably be assumed, that it might carry roughly the same risk of death like similar compounnds like DMXE or MXPr.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of MXPr can be considered moderately addictive with a high potential for abuse and is capable of producing psychological dependence among certain users. when addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

tolerance to many of the effects of MXPr develops with prolonged and repeated use. this results in users having to administer increasingly large doses to achieve the same effects. after that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).

MXPr presents cross-tolerance with all dissociatives, meaning that after the consumption of mxe all dissociatives will have a reduced effect.

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Czech Republic: MXPr is a Schedule I (List 4) substance. It may be used for research and restricted therapeutic purposes. (§ 1, d), 1. of Nařízení vlády č. 463/2013 Sb.) [1]
  • Switzerland: MXPr is specifically named under Verzeichnis E point 277.[2]
  • United Kingdom: MXPr is illegal in the United Kingdom.[citation needed]
  • United States: MXPr is not illegal, however, if it is sold with the intention for human consumption (such as in capsules) it becomes illegal to possess under the Federal Analogue Act. This is avoided by placing the label "not for human consumption" on the container of the chemical.[citation needed]

See also

External links


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