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| Summary sheet: Methcathinone |
| Methcathinone | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common names | DMT, Dimethyltryptamine, Dmitri | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substitutive name | N,N-Dimethyltryptamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systematic name | 2-(1H-Indol-3-yl)-N,N-dimethylethanamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Psychoactive class | Psychedelic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical class | Tryptamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Chemistry
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Pharmacology
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Subjective effects
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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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Toxicity and harm potential
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It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Dangerous interactions
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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
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See also
External links
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- SUBSTANCE (Wikipedia)
- SUBSTANCE (Erowid Vault)
- SUBSTANCE ([PiHKAL or TiHKAL] / Isomer Design)
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This page has not been fully approved by the PsychonautWiki administrators. It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards. |
| |
This page has not been fully approved by the PsychonautWiki administrators. It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards. |
The best defintion to edit on is NOT a single sentence about some nonsense about not dying. Might not die if the best info is back on. (Joey from bluelight.org)
| Summary sheet: Methcathinone |
| Methcathinone | |||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||
| Common names | Methcathinone, Ephedrone, Methcat, Cat, Jeff, MC | ||||||||||||||||||||||
| Substitutive name | α-methylamino-propiophenone | ||||||||||||||||||||||
| Systematic name | (RS)-2-(methylamino)-1-phenyl-propan-1-one | ||||||||||||||||||||||
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| Psychoactive class | Stimulant / Entactogen | ||||||||||||||||||||||
| Chemical class | Cathinone | ||||||||||||||||||||||
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Methcathinone (also known as Ephedrone originally, Methcat and CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.
Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.
Chemistry
Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrine reuptake inhibitor.[1] The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
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- Stimulation - Methcathinone is reported to be extremely stimulating and energetic. The style of stimulation can be described as "forced". This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present.
- Physical euphoria - Physical euphoria is very prominent when used responsibly (i.e. reasonable dosing and spacing between experiences) and can lead to profound feelings of social and physical disinhibition.
- Dehydration - The Dehydration that is experienced during a methcathinone experience is generally more severe than with other stimulants like Amphetamine. Due to this, you must take extreme care and hydrate yourself constantly, so that you do not suffer from Rhabdomyolysis. This is done generally by observing your body, if there is any pain, if your kidneys feel weird, and if your urine is yellow to green-yellow like tea. Read the wiki and inform yourself on rhabdomyolysis since it is a very bad thing to have, you could die from it if it is severe enough and untreated over long time. Generally you can mitigate it by seeing if your urine is yellow, then if it is, and you do not urinate regularly drink a glass of water every 15 or 30 minutes (as long as you don't drink too much and hurt yourself) and your urine should become clear. As Long as you keep hydrating yourself your kidneys will be normal and functioning and you will be good, keep drinking water constantly after it becomes clear, for some few more hours but a bit less amount wise so that you don't have the problem again.
- Increased heart rate - The increase in heart rate is generally weaker than with other stimulants like Methamphetamine.
- Increased perspiration - The amount of perspiration is very high. You will sweat extremely easily in hot places and if you do any physical activity. Mixing Methcathinone with DXM will make you drip drops of sweat literally all the time. Hydrate yourself due to this increased perspiration or you will lose a large amount of water very fast.
- Increased blood pressure -
- Muscle contractions - These sudden muscle contractions are experienced during the comedown. This is due to the deficiency of Dopamine in the brain, which replicates symptoms to Parkinson's disease. These tremors are temporary and will subside within a few hours.
- Muscle spasms - Typically occurs during the Comedown. This is due to depletion of Dopamine in the brain.
- Spontaneous physical sensations - The "body high" of Methcathinone can be characterized as a moderate to extreme euphoric sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. -
- Stomach cramps -
- Tactile enhancement
- Teeth grinding - This effect when experienced alongside euphoria can often lead to users mildly or intensely clenching their jaw muscles, sometimes even to the point where the individual’s facial expression begins to change. This is sometimes colloquially called “gurning”[4] and is typically only experienced in common to high dosages.
- Vasoconstriction -
Cognitive effects
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The cognitive effects of Methcathinone can be broken down into several components which progressively intensify proportional to dosage.
The most prominent of these cognitive effects generally include:
- Analysis enhancement
- Anxiety
- Cognitive euphoria - Methcathinone is extremely stimulating and energetic.
- Compulsive redosing
- Empathy, love, and sociability enhancement - This particular effect, although distinct, is far less prominent than the same effect found within traditional entactogens such as MDMA or 2C-B.
- Focus enhancement
- Increased libido or Decreased libido
- Increased music appreciation
- Memory enhancement
- Motivation enhancement
- Thought acceleration
- Thought organization
- Time distortion
- Wakefulness
- Psychosis
- Paranoia
After effects 
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
How to Dose Properly
Methcathinone, due to its nature, can often cause extreme compulsive redosing. A good strategy is to pre-plan your experience in advance. To minimalize the risk of compulsive redosing and severe negative effects, follow the below points: ▹Pre-plan the total amount of Methcathinone you will take. Limit the amount you have accessible to that amount. ▹Make a rough timeline of the experience. Plan how many re-doses you will do and when you will re-dose.
I have discovered a few ways you can use Methcathinone.
①Take a strong or heavy dose and redose twice. This is done by taking a first dose of 250-500mg (T:00:00) Afterwards you take the a redose, which is 40-50% the amount of the first dose (T:00:30-005:0) Which is then followed by a final re-dose, which is 40-50% of the first dose (T:01:15-01:45).
②Take multiple common doses. Take 150-200mg, then redose when it wears off with the same dose. Do a maximum of four doses.
0When you take a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose. So you don't comedown.
Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell. Gradually decreasing the dose instead aka a redose will make it a ton more manageable. You can then redose another 40% or leave it. But don't redose more than twice.0
0What I recommend for the comedown is that 60mins after you redosed last to take 20% of the first dose. Then to stop. That's the best method to not have a huge comedown.0
0For a mild stimulating experience, take a light dose first, then redose with a medium dose, then as a final, a medium or medium-high dose. Space the doses out more.0
Synthesis
Methcathinone is synthesised most easily by reacting Pseudoephedrine with KMnO4. The reaction is very specific though. A very specific temperature needs to be achieved, below zero, so that the oxidation is subtle and not too energetic, so that it does not destroy the Pseudoephedrine and make it into Benzaldehyde. The same goes for the amount of KMnO4, it has to be a specific ratio of oxidizer to Pseudoephedrine.
See also
- Responsible use
- Stimulants
- Cathinones
- Amphetamine
- Mephedrone
- 3-MMC (3-methylmethcathinone)
- Ethcathinone
Experience reports
Anecdotal reports which describe the effects of this compound within our experience index include:
External links
References
- ↑ Cathinone derivatives: A review of their chemistry, pharmacology and toxicology | DOI 10.1002/dta.31