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| Summary sheet: 2-MMC |
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common names | 2-MMC, Orthophedrone | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substitutive name | 2-Methylmethcathinone | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systematic name | 2-(methylamino)-1-phenylpropan-1-one | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Psychoactive class | Stimulant / Entactogen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical class | Cathinone | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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2-Methylmethcathinone (also known as 2-MMC, Ortho or Orthomephedrone) is a novel lesser-known stimulant-entactogen substance of the cathinone class that induces feelings of euphoria, and stimulation. It is related to other substituted cathinones like for example 3-MMC or 4-MMC (Mephedrone). The mechanism of action is not fully studied, but dopamine ,serotonin and norepinephrine releasing activity is known to be involved.
2-MMC is shown to be more dopaminergic and less serotonergic compared to MDMA. This profile makes it more stimulating and less empathogenic, similar to that of Amphetamine.
Subjective effects include stimulation, anxiety suppression, enhanced empathy and sociability, relaxation, increased libido, increased music appreciation and euphoria. The effects are reported to be a mix of amphetamine and a cocaine-like stimulation rush with a lighter version of MDMA euphoria. It is highly advised to use harm reduction practices if using this substance as it has a very short history of use.
History and culture
It was first identified in Sweden in May 2014.[1]. Until recently, it had beeen an obscure substance, unclassified in many countries. Cases of its use were sporadic. However, since the Dutch ban on 3-MMC, the sale and use of 2-MMC became prevalent in the Netherlands.[citation needed]
Chemistry
2-Methylmethcathinone's chemical name is 2-(methylamino)-1-phenylpropan-1-one and is a cathinone derivative, which is a synthetic form of phenylethylamines. 2-MMC has a cathinone which is substituted with a methyl group at the 2 position which makes it a structural isomer of Metaphedrone.
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Stimulation - Orthomephedrone is reported to be highly energizing and stimulating, it encourages physical activities like running, walking, or dancing. The style of stimulation can be described as "forced". This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present. Additionally, 2-MMC can produce wave-like feelings of sedation and relaxation may be paradoxically present, although this doesnt happen that frequently, it can lead users to redose.
- Bodily control enhancement
- Physical euphoria
- Stamina enhancement
- Nausea
- Headaches
- Temperature regulation suppression
- Spontaneous physical sensations
- Increased bodily temperature & *Decreased bodily temperature - Increased bodily temperature, although common on stimulants, is not experienced often by many users, ironically, most users report decreased bodily temperature or no change in temperature at all on 2-MMC.
- Increased perspiration
- Vasoconstriction
- Increased heart rate - 2-MMC increases heart rate mildly to moderately compared to other stimulants, even at higher dosages.
- Abnormal heartbeat
- Dehydration
- Dry mouth
- Vibrating vision
- Frequent urination
- Dizziness
- Tactile intensification
- Appetite suppression
- Pupil dilation
- Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.
- Orgasm depression
- Restless leg syndrome
- Temporary erectile dysfunction
- Seizure - This is a very rare effect but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, fatigued or when combining with other substances that lower the seizure threshold.
Cognitive effects 
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- Anxiety suppression
- Anxiety
- Cognitive euphoria
- Paranoia
- Disinhibition
- Empathy, affection, and sociability enhancement
- Ego inflation
- Delusion
- Cognitive euphoria
- Increased music appreciation
- Compulsive redosing
- Immersion enhancement
- Increased libido
- Memory suppression - 2-MMC's positional isomer 4-MMC has been shown to negatively impact short-term memory[2] and 2-MMC itself anecdotally is said to have immediate disruptive effects on memory.
- Motivation enhancement
- Creativity enhancement
- Thought acceleration
- Delirium & Confusion - This effect typically only occurs with overly high doses, and is associated with temperature dysregulation, sleep deprivation and overheating, particularly when 2-MMC is taken in crowded, physically strenuous environments that leaves the user unable to cool off, rest, or rehydrate adequately.
- Psychosis
- Time compression - Strong feelings of time compression are commonly produced by 2-MMC and speed up the experience of time noticeably, although this varies from person to person.
- Wakefulness
After effects 
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include: The "comedown" on 2-MMC is reported to be a smooth and clear gradual return to sobriety rather than a crash.
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Experience reports
There are currently 1 experience reports which describe the effects of this substance in our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Like other cathinones, 2-MMC remains a highly addictive substance
Dangerous interactions
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with 2-MMC should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
- Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
- MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
- MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
- Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
- Stimulants - 2-MMC may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
- Tramadol - Tramadol is known to lower the seizure threshold[3] and combinations with stimulants may further increase this risk.
- Cocaine - This combination may increase strain on the heart.
Legal status
- Germany: 2-MMC is controlled under the NpSG (New Psychoactive Substances Act)[4] as of November 26, 2016.[5] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[6]
- Poland: Illegal in Poland, the substance is not included in the list of groups of psychotropic substances, however, it falls under the group of psychotropic substances of group I-P as isomer of 3-MMC (metaphedrone) and 4-MMC (mephedrone).
See also
External links
References
- ↑ "Europol 2014 Annual Report on the implementation of Council Decision 2005/387/JHA" (PDF). European Monitoring Centre for Drugs and Drug Addiction. 10 May 2005.
- ↑ https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045473
- ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183.
- ↑ "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 19, 2019.
- ↑ "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 19, 2019.
- ↑ "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 19, 2019.