TMA-6

TMA-6, or 2,4,6-trimethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines, being comprised of a phenyl ring bound to an amino (NH₂) group through an ethyl chain and a methyl group bound to the alpha carbon R_α. TMA-6 contains methoxy functional groups CH₃O- attached to carbons R₂ and R₄ and R₆ of the amphetamine backbone.^[1]

TMA-6's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

• Experience:42 mg TMA-6: Pure Bliss

Additional experience reports can be found here:

• Erowid Experience Vaults: TMA-6

The toxicity and long-term health effects of recreational TMA-6 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-6 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-6 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

Though largely unstudied TMA-6 is largely considered to be not habit-forming and the desire to use it can actually decrease with consumption. It is most often self-regulating.

Tolerance to the effects of TMA-6 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA-6 presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA-6 all psychedelics and stimulants will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Tramadol - Tramadol lowers the seizure threshold^[2] and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.^{[citation needed]}
• Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.^{[citation needed]}
• Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.^{[citation needed]}

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

• MAOIs - Such as banisteriopsis caapi, syrian rue, phenelzine, selegiline, and moclobemide.^[3]
• Serotonin releasers - Such as MDMA, 4-FA, methamphetamine, methylone and αMT.
• SSRIs - Such as citalopram and sertraline
• SNRIs - Such as tramadol and venlafaxine
• 5-HTP

• Germany: TMA-6 is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.^[4][5] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.^[6]
• Switzerland: TMA-6 is not specifically named, although it can be considered an ether analog of an ether analog of PMA, which would make it illegal according to Buchstabe C.^[7]
• Turkey: TMA-6 is a classed as drug and is illegal to possess, produce, supply, or import.^{[8] [9]}

• Responsible use
• Research chemicals
• Psychedelics
• Phenethylamines
• Substituted amphetamines
• Alexander Shulgin
• TMPEA
• TMA-2

• Trimethoxyamphetamine (Wikipedia)
• TMA-6 (PiHKAL / Isomer Design)
• The Big & Dandy TMA Series Thread (Bluelight)