LSM-775
| Summary sheet: LSM-775 |
| LSM-775 | |||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||
| Common names | LSM-775 | ||||||||||||||||||||||||
| Substitutive name | Lysergic acid morpholide, N-Morpholinyllysergamide | ||||||||||||||||||||||||
| Systematic name | [(8β)-6-Methyl-9,10-didehydroergolin-8-yl](morpholin-4-yl)methanone | ||||||||||||||||||||||||
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| Psychoactive class | Psychedelic | ||||||||||||||||||||||||
| Chemical class | Lysergamide | ||||||||||||||||||||||||
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| Tramadol | |||||||||||||||||||||||||
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Lysergic acid morpholide (also known as N-Morpholinyllysergamide, and LSM-775) is a novel synthetic research psychedelic of the lysergamide chemical class that produces a generally similar albeit significantly less psychoactive array of LSD-like psychedelic effects when administered. It is a close structural homolog of LSD known mainly for its obscurity, low relative potency, and a few comments that have been made on the "dream-like" sedation it produces as well as potential nausea and other potentially uncomfortable physical effects.
LSM-775 was first investigated in animal models in 1957, where it was observed to be "qualitatively similar to LSD" albeit with a significantly lower potency and "half the duration".[1] It was later briefly described as one of the many analogs of LSD by Alexander Shulgin in his book TiHKAL ("Tryptamines I Have Known and Loved"), in which he mentions conflicting reports, with one stating that "75 micrograms is an effective dose, comparable to a similar dose of LSD, and the other stating that "between 350 and 700 micrograms was needed" while producing "fewer signs of cardiovascular stimulation and peripheral toxicity."[2] Since then, it has been observed that the latter observation is a more accurate description of LSM-775's potency in humans, meaning it possesses about 1/10th the potency of LSD.
Very little data exists about the pharmacological properties, metabolism, and toxicity of LSM-775, and it has very little history of human usage. It has recently appeared on the market alongside research chemical psychedelic lysergamides such as AL-LAD, ETH-LAD and PARGY-LAD as a legal, grey-market alternative to LSD, and commercially distributed through online research chemical vendors (although it is considered to be one of the least popular and available in the series). Despite its low observed potency relative to LSD, it is still highly advised to approach this unstudied hallucinogenic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.
Chemistry
LSM-775, or lysergic acid morpholide, is a synthetic alkaloid of the lysergamide family. LSM-775 is a structural analog of lysergic acid, with a morpholinyl functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative, and has overlapping tryptamine and phenethylamine groups embedded within it (although it is principally classed as a tryptamine).
Pharmacology
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This pharmacology section is incomplete. You can help by adding to it. |
LSM-775 likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from LSM-775's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.
N-Morpholinyllysergamide (LSM-775) is a derivative of ergine.[1] It is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 700 micrograms and a shorter duration. There are fewer signs of cardiovascular stimulation and peripheral toxicity with LSM-775 compared to LSD.[2]
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects 
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- Spontaneous physical sensations - The "body high" of LSM-775 can be characterized as prominent in comparison to its accompanying visual and cognitive effects. Like LSD, it can behave as a fast-moving, sharp and location specific or generalized tingling sensation, although this feeling is not necessarily pleasant and often manifests in a neutral way. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached.
- Physical euphoria - This component can occur with the development of spontaneous bodily sensations.
- Sedation
- Bodily control enhancement
- Stamina enhancement - This component is generally mild in comparison to traditional stimulants.
- Headaches
- Nausea
- Appetite suppression
- Dehydration
- Difficulty urinating or Frequent urination
- Temperature regulation suppression
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Muscle contractions
- Muscle cramps
- Muscle spasms
- Olfactory hallucination
- Mouth numbing
- Excessive yawning
- Watery eyes
- Pupil dilation
- Vasoconstriction[citation needed]
- Wakefulness
- Teeth grinding - This component is considerably less intense when compared with that of substances like MDMA.
- Seizure - This is an effect whose likelihood is largely extrapolated from the seizures that have been reported from the use of LSD. They are thought to mainly be a risk in those who are genetically predisposed to them, particularly while accompanied by physically taxing conditions such as states of dehydration, fatigue or undernourishment. The extent to which this differs from the seizure risk posed by LSD is totally unknown; however, it should be noted that there are no documented cases of seizures occurring with this compound to date.[citation needed]
- Spontaneous physical sensations - The "body high" of LSM-775 can be characterized as prominent in comparison to its accompanying visual and cognitive effects. Like LSD, it can behave as a fast-moving, sharp and location specific or generalized tingling sensation, although this feeling is not necessarily pleasant and often manifests in a neutral way. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached.
Visual effects 
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Enhancements
Distortions
- Drifting (melting, breathing, morphing and flowing)
- Brightness alteration
- Colour shifting
- Depth perception distortions
- Tracers
- After images
- Diffraction
- Perspective distortions
- Symmetrical texture repetition
Geometry
The visual geometry that is potentially present throughout this trip can be likely described as more similar in appearance to that of MET or 2C-B than psilocin, or DMT. It can be tentatively be described through its variations as primarily intricate in complexity, algorithmic in form, structured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, immersive in-depth and consistent in intensity. At higher dosages, it may almost consistently result in states of Level 8A or Level 8B visual geometry.[citation needed]
Hallucinatory states
Cognitive effects 
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The cognitive effects of LSM-775 can be broken down into several components which progressively intensify proportional to dosage. In comparison to other psychedelics such as psilocybin, AL-LAD and mescaline, LSM-775 is likely able to be described as generally more stimulating and fast-paced in terms of the specific style of thought stream(s) produced and contains a large number of potential effects. However, relative to other lysergamides, it has been noted as being more sedating and "dream-like", in a manner that has drawn comparisons to LSA.
The most prominent of these cognitive effects generally include:
- Analysis enhancement
- Anxiety & Paranoia
- Personal bias suppression
- Novelty enhancement
- Conceptual thinking
- Introspection
- Immersion enhancement
- Novelty enhancement
- Increased music appreciation
- Increased sense of humor
- Thought acceleration
- Thought connectivity
- Thought loops
- Language suppression
- Memory suppression
- Confusion
- Déjà vu
- Time distortion - This component has been reported to be particularly pronounced relative to other psychedelics.
- Wakefulness
Auditory effects 
Multi-sensory effects 
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- Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
Transpersonal effects 
- It should be noted that these effects are the rarest and least reproducible those that can occur during a psychedelic experience. They are considered unique in that that simply taking more of the substance does not necessarily increase the chance they will occur, and are said to rely more on contextual factors such as the user's set and setting rather than the substance or dose itself. Their fullest manifestations are sometimes called "peak", "transcendent" or "transformative" experiences; however, they can still occur on a conceptual or cognitive level that can leave a lasting positive impact on the user.
Combinations
- Cannabis - When used in conjunction with cannabis, both the visual and cognitive effects of LSM-775 can be intensified and extended with extreme efficiency. This should be used with caution if one is not experienced with psychedelics. Many users sometimes report a dramatically more intense visual trip when combining it with THC concentrates such as hashish as opposed to cannabis flower. However, this can also amplify the anxiety, confusion and psychosis producing aspects of both substances significantly, so extreme caution with this combination is advised.
- Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of LSM-775 have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations and confusion.
- MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of LSM-775 are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. It is often recommended to wait at least three to four hours after ingesting LSM-775 to take MDMA so as to avoid coming down from the latter while peaking on the former. The synergy between these substances is unpredictable (and likely neurotoxic)[citation needed], and it is best to start with lower dosages than one would take for both substances individually.
- Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea, and physical fatigue which can negatively affect a trip if taken in in moderate to dosages. This combination is however reasonably safe in low doses and when used responsibly, this can often take the edge off a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more stressful on the body.
- Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a LSM-775 trip. They are very efficient at stopping bad trips at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
- Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with lower dosages than one would take for either substance individually.
Experience reports
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational LSM-775 do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because LSM-775 is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried LSM-775 suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
While no formal studies have been conducted, LSM-775 is likely not habit-forming and it is reasonable to speculate that the desire to use it can actually decrease with repeated administratinon. As with most psychedelics, it likely possesses what is considered an intrinsic, self-regulating aspect to it.
Tolerance to the effects of LSM-775 is built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). LSM-775 likely presents cross-tolerance with all psychedelics, meaning that after the consumption of LSM-775 all psychedelics will have a reduced effect.
Dangerous interactions
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
- Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of LSM-775. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
- Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.[citation needed]
- Tramadol - Tramadol is well-documented to lower the seizure threshold[3] and psychedelics may act to trigger seizures in susceptible individuals.[citation needed]
Legal status
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This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
- Germany: LSM-775 is controlled under the NpSG (New Psychoactive Substances Act)[4] as of July 18, 2019.[5] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[6]
- Switzerland: LSM-775 can be considered a controlled substance as a defined derivative (Alkoxyalkyl) of Lysergic Acid under Verzeichnis E point 263. It is legal when used for scientific or industrial use.[7]
See also
External links
Literature
- Gogerty, J. H., & Dille, J. M. (1957). Pharmacology of d-lysergic acid morpholide (LSM). Journal of Pharmacology and Experimental Therapeutics, 120(3), 340-348. PMID: 13476356
References
- ↑ 1.0 1.1 Gogerty, J. H.; Dille, J. M. (1957). "Pharmacology of d-lysergic acid morpholide (LSM)". Journal of Pharmacology and Experimental Therapeutics. 120 (3): 340–348. eISSN 1521-0103. ISSN 0022-3565. OCLC 1606914. PMID 13476356.
- ↑ 2.0 2.1 Shulgin, Alexander; Shulgin, Ann (1997). "#26. LSD-25". TiHKAL: The Continuation. United States: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
- ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039.
- ↑ "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
- ↑ "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. Retrieved January 1, 2020.
- ↑ "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
- ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020.