2C-T

It was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin.^[3] However, 2C-T is almost unknown on the black market and is rarely sold online.

2C-T is in a class of compounds commonly known as phenethylamines, and is the 4-methylthio analogue of 2C-O, a positional isomer of mescaline. It is also the 2C analog of Aleph. The systematic name of the chemical is 2-(2,5-dimethoxy-4-(methylthio)phenyl)ethanamine. The CAS number of 2C-T is 61638-09-3.

2C-T, or 2,5-dimethoxy-4-methylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through a methyl chain. 2C-T belongs to the 2C family of phenethylamines which contain methoxy functional groups CH₃O- attached to carbons R₂ and R₅ of the benzene ring. 2C-T is also substituted at R₄ with an methyl thioether group.

The mechanism of action that produces 2C-T’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT_2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Being similar in structure to 2C-T-2 and 2C-T-7, this compound may have some MAOI properties.

The effects of 2C-T have been described as being less visual and more in the body.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 2C-T

The toxicity and long-term health effects of recreational 2C-T use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

Anecdotal reports suggest that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this substance.

Dependence and abuse potential

2C-T is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Although only speculative, it is worth noting that if 2C-T does have MAOI effects this could indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.^[4] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

• Canada: 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.^[5]
• Germany: 2C-H is controlled under the NpSG^[6] (New Psychoactive Substances Act) as of November 26, 2016.^[7] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.^[8][9] The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.^[10]
• United Kingdom: 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.^[11]
• United States: 2C-T is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.^{[citation needed]}

• Responsible use
  • Volumetric liquid dosing
• Research chemical
• 2C-x
• 2C-T-2
• 2C-T-7
• 2C-E

• 2C-T (Wikipedia)
• 2C-T (PiHKAL / Isomer Design)

Discussion

• The Big & Dandy 2C-T Thread (Bluelight)